Inhibition of H1N1 Influenza Virus-induced Apoptosis by Ebselen Through ROS-mediated ATM/ATR Signaling PathwaysArticle Published on 2023-06-012023-06-23 Journal: Biological trace element research [Category] 신종인플루엔자, [키워드] Apoptosis Ebselen Influenza mechanism oxidative damage. [DOI] 10.1007/s12011-022-03369-2 PMC 바로가기
COVID-19: the possibility, ways, mechanisms, and interruptions of mother-to-child transmissionReview Published on 2023-06-012023-07-09 Journal: Archives of gynecology and obstetrics [Category] COVID19(2023년), [키워드] mechanism Mother-to-child transmission prevention SARS-CoV-2. [DOI] 10.1007/s00404-022-06639-5 PMC 바로가기 [Article Type] Review
Machine learning and protein allosteryReview Published on 2023-04-012023-07-11 Journal: Trends in biochemical sciences [Category] COVID19(2023년), [키워드] Allostery Drug discovery machine learning mechanism prediction protein design. [DOI] 10.1016/j.tibs.2022.12.001 PMC 바로가기 [Article Type] Review
Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathwayArticle Published on 2023-01-302022-11-16 Journal: Journal of ethnopharmacology [Category] 신종인플루엔자, 치료기술, [키워드] acute lung injury analyzed Anti-inflammation Apoptosis approved attenuate BALF Bcl-xL caspase Cell changes China confocal microscope coronavirus COVID-19 declined downstream drug Effect expression fatal complication flow cytometry food Granule H1N1 influenza histological histopathological IL-1β IL-6 immunofluorescence Infectious disease Influenza virus inhibited injection intrinsic investigated Jinhua Qinggan granules LPS lung Lung injury Lungs material mechanism mice Mild mitochondrial apoptotic pathway moderate morbidity and mortality MPO neutrophil Neutrophil apoptosis novel coronavirus disease Nuclear factor kappa-B nuclei p65 pathway pharmacological positive proportion Protein protein concentration protein expression pulmonary inflammation receptor reduced Respiratory disease Respiratory virus infection Signaling signaling pathway significantly staining survival survival rate TLR4 TNF-α Toll-like receptor 4. treated Treatment were assessed were measured [DOI] 10.1016/j.jep.2022.115763 PMC 바로가기
Vitamin D-A prominent immunomodulator to prevent COVID-19 infectionReview Published on 2023-01-012023-07-10 Journal: International journal of rheumatic diseases [Category] COVID19(2023년), [키워드] doses immune system mechanism severe acute respiratory syndrome coronavirus 2 vitamin D. [DOI] 10.1111/1756-185X.14477 PMC 바로가기 [Article Type] Review
A comprehensive review of SARS-CoV-2 vaccines: Pfizer, Moderna & Johnson & JohnsonSARS-CoV-2 백신에 대한 포괄적인 검토: Pfizer, Moderna & Johnson & JohnsonReview Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, [키워드] Adenovirus administration age approval clinical clinical trial clinical trials coronavirus coronavirus. COVID-19 COVID-19 vaccine COVID-19 vaccines effective Efficacy General population group Johnson Johnson & Johnson Johnson & large cohort mechanism moderate Moderna mRNA vaccines Novel coronavirus ongoing trial ongoing trials outbreak pandemic participant Pfizer Safety SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection shown Side effects Spike protein symptomatic SARS-CoV-2 infection tested the SARS-CoV-2 the spike protein the United State Trial United States Vaccinations Vaccine vaccine administration variant [DOI] 10.1080/21645515.2021.2002083 PMC 바로가기 [Article Type] Review
A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain원숭이와 생쥐의 비교 miRNA 전사체는 MYOC가 뇌로의 크립토코커스 네오포르만스 침입에 대한 억제제임을 보여줍니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] 유전자 메커니즘, [키워드] AIDS Brain brain dissemination brains C. neoforman C. neoformans caused Central nervous system centric clinical samples clinically CNS Comparative Cryptococcal meningoencephalitis cryptococcosis Cryptococcus neoforman Cryptococcus neoformans cytoskeleton dissemination enhancer facilitate fungal Fungal infection help HIV/AIDS HIV/AIDS patient HIV/AIDS patients host-pathogen interactions hosts human pathogen Immune cell immune cells individuals Infection inhibitor inhibitors Invasion macaque Macrophage mechanism meningoencephalitis mice miRNA miRNA transcriptome. MYOC myocilin Pathogenic microorganisms pathway Patient patients with COVID-19 performed Prevalence regulated response reveal Transcriptome transcriptomics Trojan horse [DOI] 10.1080/22221751.2022.2081619 PMC 바로가기 [Article Type] Article
Structure-based neutralizing mechanisms for SARS-CoV-2 antibodiesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, [키워드] antibody Antibody structure caused consequence COVID-19 pandemic Critical cryo-EM develop effective effort epitope Host Infection mAbs mechanism molecular monoclonal antibody Neutralizing neutralizing antibody neutralizing mechanism pan-coronavirus vaccine. provide public health SARS-CoV-2 SARS-CoV-2 antibody Scientific community the spike protein Vaccine Vaccines [DOI] 10.1080/22221751.2022.2125348 PMC 바로가기
COVID-19 and inflammatory bowel disease crosstalk: From emerging association to clinical proposalArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] abdominal pain ACE2 acute respiratory syndrome addition association Autoimmune bowel Care caused coronavirus coronavirus disease COVID-19 COVID-19 epidemic diarrhea disease downregulated enzyme Epidemic etiology exacerbate expressed feasibility Genetic IBD IL-17 Imbalance immune activation immunosuppressive drug increase induce Infection Inflammatory Inflammatory bowel disease inflammatory bowel disease. inflammatory disease Inflammatory response intestinal intestinal inflammation intestine lung mechanism nonspecific overlapping pathway Patient patients Pneumonia progression protective factor receptor Research respiratory inflammation risk risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection Symptom systemic symptom the cytokine storm the SARS-CoV-2 Treatment upregulated vaccination [DOI] 10.1002/jmv.28067 PMC 바로가기